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Publication Year: 2023

1,241 to 1,250 of 1,452 Results

Suppressing STAT3 activation impairs bone formation during maxillary expansion and relapse Mar 28, 2023 - Journal of Applied Oral Science Wang, Si; Xiao, Xiaoyue; Chen, Jianwei; Zhai, Qiming; Xin, Liangjing; Zheng, Xinhui; Song, Jinlin, 2023, "Suppressing STAT3 activation impairs bone formation during maxillary expansion and relapse", https://doi.org/10.48331/scielodata.37EU59, SciELO Data, V1 Objectives: The mid-palatal expansion technique is commonly used to correct maxilla constriction in dental clinics. There is, however, a tendency for it to relapse, and the key molecules responsible for modulating bone formation remain elusive. Thus, this study aimed to investiga...
Figure_1.jpg Mar 28, 2023 - Suppressing STAT3 activation impairs bone formation during maxillary expansion and relapse JPEG Image - 428.3 KB - MD5: 102bb332f5f3acc5742cc5a2881e884d Figure 1. Schematic diagram of expansion appliances used in the study. A, Inactivated expander. B, Activated expander. C, 100 g expansion force was exerted when the expander was installed on the occlusal surface of molars.
Figure_2.jpg Mar 28, 2023 - Suppressing STAT3 activation impairs bone formation during maxillary expansion and relapse JPEG Image - 76.3 KB - MD5: 4c205748ad89f6b72872351a592528c9 Figure 2. Arch width changes and Micro-CT analysis. A, Arch width measurements. B, BV/TV change. C, TbN value change. *P < 0.05
Figure_3.jpg Mar 28, 2023 - Suppressing STAT3 activation impairs bone formation during maxillary expansion and relapse JPEG Image - 660.0 KB - MD5: 9779e88a88cf2661a38d164546ebef32 Figure 3. HE staining of the mid-palatal suture
Figure_4.jpg Mar 28, 2023 - Suppressing STAT3 activation impairs bone formation during maxillary expansion and relapse JPEG Image - 944.6 KB - MD5: f093157c9226a03ad04e6c95299779b3 Figure 4. Masson staining of the mid-palatal suture
Figure_5.jpg Mar 28, 2023 - Suppressing STAT3 activation impairs bone formation during maxillary expansion and relapse JPEG Image - 2.3 MB - MD5: 8a88c3a1d6b38ab3199b1d2389496311 Figure 5. Russell-Movat pentachrome staining of the mid-palatal suture
Figure_6.jpg Mar 28, 2023 - Suppressing STAT3 activation impairs bone formation during maxillary expansion and relapse JPEG Image - 1.0 MB - MD5: 61dff293fd00bf1e8ac68302950da28b Figure 6. Osteogenesis-related factors and osteoclast activity were influenced by palatal expansion and STAT3 inhibition. A, C, E, Immunohistochemical staining of COL-I, Runx2, and ALP. B, D, F, Semiquantitative analysis of COL-I, Runx2, and ALP expression in the mid-palatal sutu...
Figure_7.jpg Mar 28, 2023 - Suppressing STAT3 activation impairs bone formation during maxillary expansion and relapse JPEG Image - 587.9 KB - MD5: 9dc1344c4edc0fc13099857f81b29ffa Figure 7. Osteoblastic STAT3 mediated the mechanical loading-increased osteogenesis. A-B, The protein levels of JAK2, pJAK2, STAT3, and pSTAT3. C-D, The protein levels of Runx2, COL-I, Osterix, and ALP. E-F, Alizarin red staining and ALP staining. *P < 0.05
Readme.txt Mar 28, 2023 - Suppressing STAT3 activation impairs bone formation during maxillary expansion and relapse Plain Text - 2.2 KB - MD5: 671ef8f57bb8d88fc2428e77ee65cdef
Supplementary_Figure_1.jpg Mar 28, 2023 - Suppressing STAT3 activation impairs bone formation during maxillary expansion and relapse JPEG Image - 459.5 KB - MD5: 4672504ff0a0e6afaa6adc3543ae6ce4 Supplementary Figure 1. Stattic administration inhibited pSTAT3 expression in MPS region. A, Immunohistochemical staining of pSTAT3. B, Semiquantitative analysis of pSTAT3. *p<0.05

Suppressing STAT3 activation impairs bone formation during maxillary expansion and relapse

Mar 28, 2023 - Journal of Applied Oral Science

Wang, Si; Xiao, Xiaoyue; Chen, Jianwei; Zhai, Qiming; Xin, Liangjing; Zheng, Xinhui; Song, Jinlin, 2023, "Suppressing STAT3 activation impairs bone formation during maxillary expansion and relapse", https://doi.org/10.48331/scielodata.37EU59, SciELO Data, V1

Objectives: The mid-palatal expansion technique is commonly used to correct maxilla constriction in dental clinics. There is, however, a tendency for it to relapse, and the key molecules responsible for modulating bone formation remain elusive. Thus, this study aimed to investiga...

Figure_1.jpg

Mar 28, 2023 - Suppressing STAT3 activation impairs bone formation during maxillary expansion and relapse

JPEG Image - 428.3 KB -

Figure 1. Schematic diagram of expansion appliances used in the study. A, Inactivated expander. B, Activated expander. C, 100 g expansion force was exerted when the expander was installed on the occlusal surface of molars.

Figure_2.jpg

Mar 28, 2023 - Suppressing STAT3 activation impairs bone formation during maxillary expansion and relapse

JPEG Image - 76.3 KB -

Figure 2. Arch width changes and Micro-CT analysis. A, Arch width measurements. B, BV/TV change. C, TbN value change. *P < 0.05

Figure_3.jpg

Mar 28, 2023 - Suppressing STAT3 activation impairs bone formation during maxillary expansion and relapse

JPEG Image - 660.0 KB -

Figure 3. HE staining of the mid-palatal suture

Figure_4.jpg

Mar 28, 2023 - Suppressing STAT3 activation impairs bone formation during maxillary expansion and relapse

JPEG Image - 944.6 KB -

Figure 4. Masson staining of the mid-palatal suture

Figure_5.jpg

Mar 28, 2023 - Suppressing STAT3 activation impairs bone formation during maxillary expansion and relapse

JPEG Image - 2.3 MB -

Figure 5. Russell-Movat pentachrome staining of the mid-palatal suture

Figure_6.jpg

Mar 28, 2023 - Suppressing STAT3 activation impairs bone formation during maxillary expansion and relapse

JPEG Image - 1.0 MB -

Figure 6. Osteogenesis-related factors and osteoclast activity were influenced by palatal expansion and STAT3 inhibition. A, C, E, Immunohistochemical staining of COL-I, Runx2, and ALP. B, D, F, Semiquantitative analysis of COL-I, Runx2, and ALP expression in the mid-palatal sutu...

Figure_7.jpg

Mar 28, 2023 - Suppressing STAT3 activation impairs bone formation during maxillary expansion and relapse

JPEG Image - 587.9 KB -

Figure 7. Osteoblastic STAT3 mediated the mechanical loading-increased osteogenesis. A-B, The protein levels of JAK2, pJAK2, STAT3, and pSTAT3. C-D, The protein levels of Runx2, COL-I, Osterix, and ALP. E-F, Alizarin red staining and ALP staining. *P < 0.05

Readme.txt

Mar 28, 2023 - Suppressing STAT3 activation impairs bone formation during maxillary expansion and relapse

Plain Text - 2.2 KB -

Supplementary_Figure_1.jpg

Mar 28, 2023 - Suppressing STAT3 activation impairs bone formation during maxillary expansion and relapse

JPEG Image - 459.5 KB -

Supplementary Figure 1. Stattic administration inhibited pSTAT3 expression in MPS region. A, Immunohistochemical staining of pSTAT3. B, Semiquantitative analysis of pSTAT3. *p<0.05

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