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JPEG Image - 428.3 KB - MD5: 102bb332f5f3acc5742cc5a2881e884d
Figure 1. Schematic diagram of expansion appliances used in the study. A, Inactivated expander. B, Activated expander. C, 100 g expansion force was exerted when the expander was installed on the occlusal surface of molars.
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Figure 2. Arch width changes and Micro-CT analysis. A, Arch width measurements. B, BV/TV change. C, TbN value change. *P < 0.05
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Figure 3. HE staining of the mid-palatal suture
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Figure 4. Masson staining of the mid-palatal suture
JPEG Image - 2.3 MB - MD5: 8a88c3a1d6b38ab3199b1d2389496311
Figure 5. Russell-Movat pentachrome staining of the mid-palatal suture
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Figure 6. Osteogenesis-related factors and osteoclast activity were influenced by palatal expansion and STAT3 inhibition. A, C, E, Immunohistochemical staining of COL-I, Runx2, and ALP. B, D, F, Semiquantitative analysis of COL-I, Runx2, and ALP expression in the mid-palatal sutu...
JPEG Image - 587.9 KB - MD5: 9dc1344c4edc0fc13099857f81b29ffa
Figure 7. Osteoblastic STAT3 mediated the mechanical loading-increased osteogenesis. A-B, The protein levels of JAK2, pJAK2, STAT3, and pSTAT3. C-D, The protein levels of Runx2, COL-I, Osterix, and ALP. E-F, Alizarin red staining and ALP staining. *P < 0.05
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Supplementary Figure 1. Stattic administration inhibited pSTAT3 expression in MPS region. A, Immunohistochemical staining of pSTAT3. B, Semiquantitative analysis of pSTAT3. *p<0.05
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Supplementary Figure 2. Preliminary experiment to confirm the effectiveness of Stattic on inhibiting STAT3 phosphorylation
JPEG Image - 6.1 MB - MD5: d890be11ade6ebbfcf3cb9bf0f8463ac
Mapa de apresentação da área de estudo com informações sobre a localização das zonas de tráfego contiguas à rodovia, travessias existentes e o traçado da PR-445.
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