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Mar 28, 2023 -
Suppressing STAT3 activation impairs bone formation during maxillary expansion and relapse
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Figure 2. Arch width changes and Micro-CT analysis. A, Arch width measurements. B, BV/TV change. C, TbN value change. *P < 0.05 |
Mar 28, 2023 -
Suppressing STAT3 activation impairs bone formation during maxillary expansion and relapse
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Figure 3. HE staining of the mid-palatal suture |
Mar 28, 2023 -
Suppressing STAT3 activation impairs bone formation during maxillary expansion and relapse
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Figure 4. Masson staining of the mid-palatal suture |
Mar 28, 2023 -
Suppressing STAT3 activation impairs bone formation during maxillary expansion and relapse
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Figure 5. Russell-Movat pentachrome staining of the mid-palatal suture |
Mar 28, 2023 -
Suppressing STAT3 activation impairs bone formation during maxillary expansion and relapse
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Figure 6. Osteogenesis-related factors and osteoclast activity were influenced by palatal expansion and STAT3 inhibition. A, C, E, Immunohistochemical staining of COL-I, Runx2, and ALP. B, D, F, Semiquantitative analysis of COL-I, Runx2, and ALP expression in the mid-palatal sutu... |
Mar 28, 2023 -
Suppressing STAT3 activation impairs bone formation during maxillary expansion and relapse
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Figure 7. Osteoblastic STAT3 mediated the mechanical loading-increased osteogenesis. A-B, The protein levels of JAK2, pJAK2, STAT3, and pSTAT3. C-D, The protein levels of Runx2, COL-I, Osterix, and ALP. E-F, Alizarin red staining and ALP staining. *P < 0.05 |
Mar 28, 2023 -
Suppressing STAT3 activation impairs bone formation during maxillary expansion and relapse
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Mar 28, 2023 -
Suppressing STAT3 activation impairs bone formation during maxillary expansion and relapse
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Supplementary Figure 1. Stattic administration inhibited pSTAT3 expression in MPS region. A, Immunohistochemical staining of pSTAT3. B, Semiquantitative analysis of pSTAT3. *p<0.05 |
Mar 28, 2023 -
Suppressing STAT3 activation impairs bone formation during maxillary expansion and relapse
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Supplementary Figure 2. Preliminary experiment to confirm the effectiveness of Stattic on inhibiting STAT3 phosphorylation |
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