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1,071 to 1,080 of 1,434 Results
Apr 17, 2023 - Journal of Applied Oral Science
Afonso, Julieta; Gholami, Shakiba; Chamorro-Petronacci, Cintia; Pérez-Sayáns, Mario; Suárez Peñaranda, José; Longatto-Filho, Adhemar; Baltazar, Fátima, 2023, "Data for: Immunoexpression profile of hypoxia-inducible factor (HIF) targets in potentially malignant and malignant oral lesions: A pilot study", https://doi.org/10.48331/scielodata.QK4JEI, SciELO Data, V1, UNF:6:hPLEZ6XG3Zfk2Mec0kzS1g== [fileUNF]
The study aimed to evaluate the immunoexpression of the HIF targets GLUT1, GLUT3, HK2, PFKL, PKM2, pPDH, LDHA, MCT4 and CAIX in tissue samples from 34 patients with oral potentially malignant disorders and 34 patients with oral squamous cell carcinoma, in order to identify potent...
JPEG Image - 570.0 KB - MD5: 90d7efa33c3e1e0a38c1b27dcfa2a2de
Figure_1 - Representative images of a haematoxylin & eosin stained oral squamous cell carcinoma section demonstrating normoxic (N) areas with integrate blood microvessels (V), and hypoxic (H) compartments where distorted and packaged vessel structures with haemorrhagic spots (v)...
JPEG Image - 224.2 KB - MD5: 758ba4a7cb0767f4a639a900e182a873
Figure_2 - Representative images of the immunohistochemical staining reactions of GLUT1, GLUT3, HK2, PFKL, PKM2, pPDH, LDHA, MCT4 and CAIX in oral potentially malignant disorders and in oral squamous cell carcinoma cases.
JPEG Image - 264.8 KB - MD5: b74e0409502d7b94235f5464b0aafd53
Figure_3 - Detailed heatmap on the immunoexpression results of GLUT1, GLUT3, HK2, PFKL, PKM2, pPDH, LDHA, MCT4 and CAIX in oral potentially malignant disorders and in oral squamous cell carcinoma (normoxic regions) cases, for the development of a glycolytic phenotype.
JPEG Image - 131.4 KB - MD5: 2a6220ce3d9bf7a69301eed2e11811e9
Figure_4 - Kaplan-Meier curve demonstrating 3-year disease-free survival based on HK2 (A), and 3-year overall survival based on HK2 (B) and CAIX (C) immunoexpression status (normoxic regions), and on the glycolytic phenotype (according to the number of positive biomarkers) of pat...
JPEG Image - 99.6 KB - MD5: 8771da16a24a957362d97f9b82a53dc0
Figure_5 - Immunoexpression of GLUT1, GLUT3, HK2, PFKL, PKM2, pPDH, LDHA and MCT4 in normoxic versus hypoxic compartments of oral squamous cell carcinoma cases.
JPEG Image - 96.5 KB - MD5: 0bcb6a20ae60ab18463d1b04c6e10035
Figure_6 - Kaplan-Meier curve demonstrating 3-year overall survival based on GLUT1 (A) and GLUT3 (B), and 3-year disease-free survival based on HK2 (C) immunoexpression status (hypoxic regions) of patients with oral squamous cell carcinoma.
JPEG Image - 234.9 KB - MD5: ff0fcb57d0fc460985126d63b66178e9
Figure_S1 - Grading system used for the evaluation of immunohistochemistry results.
JPEG Image - 262.9 KB - MD5: 12ae6668a4ef9199afd79840616fe1fe
Figure_S2 - Representative images of the immunohistochemical staining reactions for GLUT1 in white oral lichen planus (A), oral leukoplakia without dysplasia (B), oral leukoplakia with low grade dysplasia (C), oral leukoplakia with high grade dysplasia (D) and oral squamous cell...
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