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Publication Year: 2024

651 to 660 of 1,576 Results

Figure_4.jpg Aug 30, 2024 - Replication Data for: The dynamin inhibitor, dynasore, prevents zoledronate-induced viability loss in human gingival fibroblasts by partially blocking zoledronate uptake and inhibiting endosomal acidification JPEG Image - 136.2 KB - MD5: 38ff2dbcf169524a0ac3ae289a7d7a82 Confocal fluorescence microscopy to determine whether dextran and ZOL colocalize in HGFs. From the same experiment, a representative photomicrograph of an HGF in the absence of Dynasore (A, C, E, and G) and a representative photomicrograph of an HGF in the presence of Dynasore (B...
Figure_5.jpg Aug 30, 2024 - Replication Data for: The dynamin inhibitor, dynasore, prevents zoledronate-induced viability loss in human gingival fibroblasts by partially blocking zoledronate uptake and inhibiting endosomal acidification JPEG Image - 238.1 KB - MD5: 1848dacb3313d0438b270a286ed930bd Confocal fluorescence microscopy of live HGFs exposed to LysoSensor Green DND-189 to measure endosomal acidification. Representative field of HGFs in the absence (A) and presence (B) of 30 microM Dynasore in which the exposure settings were kept constant. 20X objective, scale bar...
Figure_6 .jpg Aug 30, 2024 - Replication Data for: The dynamin inhibitor, dynasore, prevents zoledronate-induced viability loss in human gingival fibroblasts by partially blocking zoledronate uptake and inhibiting endosomal acidification JPEG Image - 111.2 KB - MD5: a264a0113bfaeea8a79565c42aabc60d Measurement of the perinuclear localization of ZOL and the positive control for macropinocytosis, dextran, in the absence and presence of 30 microM Dynasore. Violin plots display the HGF perinuclear proportion of intracellular TRITC-dextran (A) and AF647-ZOL (D) fluorescence. Hor...
Graphical_Abstract.pdf Aug 30, 2024 - Replication Data for: The dynamin inhibitor, dynasore, prevents zoledronate-induced viability loss in human gingival fibroblasts by partially blocking zoledronate uptake and inhibiting endosomal acidification Adobe PDF - 84.1 KB - MD5: 496fd3da516f74ba23d636c4a2e04675 Text summary and data displaying the major findings.
HGFIMIRescue_DataGraph.jpg Aug 30, 2024 - Replication Data for: The dynamin inhibitor, dynasore, prevents zoledronate-induced viability loss in human gingival fibroblasts by partially blocking zoledronate uptake and inhibiting endosomal acidification JPEG Image - 66.2 KB - MD5: db50edfaef672c4413910622875fe627 This graph displays the "data not shown" in the Dynasore rescue portion of Results. An optimized dose of imipramine (IMI) of 25 microM for one hour prior to 72 hours of incubation in the presence of zoledronate does not rescue the 50 microM zoledronate (ZOL)-treated HGFs. Error b...
HGFIMIRescue_PercentViabilityData.tab Aug 30, 2024 - Replication Data for: The dynamin inhibitor, dynasore, prevents zoledronate-induced viability loss in human gingival fibroblasts by partially blocking zoledronate uptake and inhibiting endosomal acidification Tabular Data - 1.9 KB - 11 Variables, 25 Observations - UNF:6:cShYK+KhoIAqGIBEkEIfQQ== This file contains the data used to make the graph that was "data not shown" in the Dynasore rescue portion of Results. The graph is the file entitled "HGFIMIRescue_DataGraph.jpg" and uploaded separately in the dataset. This graph shows that an optimized dose of imipramine (IMI)...
OsteoblastPFARescue_DataGraph.jpg Aug 30, 2024 - Replication Data for: The dynamin inhibitor, dynasore, prevents zoledronate-induced viability loss in human gingival fibroblasts by partially blocking zoledronate uptake and inhibiting endosomal acidification JPEG Image - 62.9 KB - MD5: d3c779177990d91baf6a82fa93ff3a1e This graph shows that optimized doses of phosphonoformic acid (PFA) from 0.25-0.75 mM for either a one-hour pre-treatment (PRE) prior or continual exposure during 72 hours of incubation in the presence of zoledronate do not rescue the 50 microM zoledronate (ZOL)-treated human cal...
OsteoblastPFARescue_PercentViabilityData.tab Aug 30, 2024 - Replication Data for: The dynamin inhibitor, dynasore, prevents zoledronate-induced viability loss in human gingival fibroblasts by partially blocking zoledronate uptake and inhibiting endosomal acidification Tabular Data - 1.8 KB - 17 Variables, 13 Observations - UNF:6:Tt8WyaVO2OzMPxxG+C8knQ== This file contains the data used to make the graph that was part of the "data not shown" in the PFA rescue portion of Results. The graph is the file entitled "OsteoblastPFARescue_DataGraph.jpg" and uploaded separately in the dataset. This graph shows that optimized doses of phosp...
OsteoclastPFARescue_DataGraph.jpg Aug 30, 2024 - Replication Data for: The dynamin inhibitor, dynasore, prevents zoledronate-induced viability loss in human gingival fibroblasts by partially blocking zoledronate uptake and inhibiting endosomal acidification JPEG Image - 61.0 KB - MD5: 67fae0c673edb167b8ee575b1ea088dc This graph shows that optimized doses of phosphonoformic acid (PFA) from 0.25-0.75 mM for either a one-hour pre-treatment (PRE) prior or continual exposure during 72 hours of incubation in the presence of zoledronate do not rescue the 50 microM zoledronate (ZOL)-treated RAW264.7,...
OsteoclastPFARescue_PercentViabilityData.tab Aug 30, 2024 - Replication Data for: The dynamin inhibitor, dynasore, prevents zoledronate-induced viability loss in human gingival fibroblasts by partially blocking zoledronate uptake and inhibiting endosomal acidification Tabular Data - 1.8 KB - 17 Variables, 14 Observations - UNF:6:fZyZ30dH8XFjiBR6clfroA== This file contains the data used to make the graph that was part of the "data not shown" in the PFA rescue portion of Results. The graph is the file entitled "OsteoclastPFARescue_DataGraph.jpg" and uploaded separately in the dataset. This graph shows that optimized doses of phosp...

Figure_4.jpg

Aug 30, 2024 - Replication Data for: The dynamin inhibitor, dynasore, prevents zoledronate-induced viability loss in human gingival fibroblasts by partially blocking zoledronate uptake and inhibiting endosomal acidification

JPEG Image - 136.2 KB -

Confocal fluorescence microscopy to determine whether dextran and ZOL colocalize in HGFs. From the same experiment, a representative photomicrograph of an HGF in the absence of Dynasore (A, C, E, and G) and a representative photomicrograph of an HGF in the presence of Dynasore (B...

Figure_5.jpg

JPEG Image - 238.1 KB -

Confocal fluorescence microscopy of live HGFs exposed to LysoSensor Green DND-189 to measure endosomal acidification. Representative field of HGFs in the absence (A) and presence (B) of 30 microM Dynasore in which the exposure settings were kept constant. 20X objective, scale bar...

Figure_6 .jpg

JPEG Image - 111.2 KB -

Measurement of the perinuclear localization of ZOL and the positive control for macropinocytosis, dextran, in the absence and presence of 30 microM Dynasore. Violin plots display the HGF perinuclear proportion of intracellular TRITC-dextran (A) and AF647-ZOL (D) fluorescence. Hor...

Graphical_Abstract.pdf

Adobe PDF - 84.1 KB -

Text summary and data displaying the major findings.

HGFIMIRescue_DataGraph.jpg

JPEG Image - 66.2 KB -

This graph displays the "data not shown" in the Dynasore rescue portion of Results. An optimized dose of imipramine (IMI) of 25 microM for one hour prior to 72 hours of incubation in the presence of zoledronate does not rescue the 50 microM zoledronate (ZOL)-treated HGFs. Error b...

HGFIMIRescue_PercentViabilityData.tab

Tabular Data - 1.9 KB - 11 Variables, 25 Observations -

This file contains the data used to make the graph that was "data not shown" in the Dynasore rescue portion of Results. The graph is the file entitled "HGFIMIRescue_DataGraph.jpg" and uploaded separately in the dataset. This graph shows that an optimized dose of imipramine (IMI)...

OsteoblastPFARescue_DataGraph.jpg

JPEG Image - 62.9 KB -

This graph shows that optimized doses of phosphonoformic acid (PFA) from 0.25-0.75 mM for either a one-hour pre-treatment (PRE) prior or continual exposure during 72 hours of incubation in the presence of zoledronate do not rescue the 50 microM zoledronate (ZOL)-treated human cal...

OsteoblastPFARescue_PercentViabilityData.tab

Tabular Data - 1.8 KB - 17 Variables, 13 Observations -

This file contains the data used to make the graph that was part of the "data not shown" in the PFA rescue portion of Results. The graph is the file entitled "OsteoblastPFARescue_DataGraph.jpg" and uploaded separately in the dataset. This graph shows that optimized doses of phosp...

OsteoclastPFARescue_DataGraph.jpg

JPEG Image - 61.0 KB -

OsteoclastPFARescue_PercentViabilityData.tab

Tabular Data - 1.8 KB - 17 Variables, 14 Observations -

This file contains the data used to make the graph that was part of the "data not shown" in the PFA rescue portion of Results. The graph is the file entitled "OsteoclastPFARescue_DataGraph.jpg" and uploaded separately in the dataset. This graph shows that optimized doses of phosp...

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