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MD5: abafa657105c56dd5b28a0cef273d725
Arquivo no formato .txt com a descrição detalhada da metodologia para a compreensão da natureza dos dados |
Trevizol, Juliana Sanches; Dionizio, Aline; Delgado, Aislan Quintiliano; Ventura, Talita Mendes Oliveira; Ribeiro, Caroline Fernanda da Silva; Ribeiro, Laura; Buzalaf, Nathalia Rabelo; Cestari, Tânia Mary; Magalhães, Ana Carolina; Suzuki, Maiko; Bosqueiro, José Roberto; Buzalaf, Marília Afonso Rabelo, 2023, "Metabolic effect of low levels of fluoride in the islets of NOD mice", https://doi.org/10.48331/scielodata.3XXS60, SciELO Data, V1
Introduction: Fluoride (F) has been largely employed for the control of dental caries, in addition to studies suggesting beneficial effects against diabetes when a low dose of F is added in the drinking water (10 mgF/L). Objectives: This study evaluated metabolic changes in the p... |
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MD5: 1857efe62a3f3d94566f680494381930
Average percentage: (A) area occupied by islets; (B) inflammatory cell infiltrate; (C) Histone H3 acetylation (acH3K14)-labeling; (D) insulin-labeling and (E) glucagon-labeling in the pancreas of female NOD mice treated with water containing 10 mgF/L or not (control) for 20 weeks... |
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MD5: d105e947c9c9c0f3e768c8acb74fcbfb
Sections of pancreas from 20-week-old female NOD mice treated with deionized water (control) (A, B, C and D) or with water containing 10 mgF/L (as NaF) for 14 weeks (E, F, G and H). A and E images show H&E staining, with presence of islets inflammatory infiltrate. B, C, F and G i... |
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MD5: 32a9ad755103de7359a2fce9b51cab30
Functional distribution of proteins identified with differential expression in the islets of female NOD mice treated with 10 mgF/L vs. Control Group (0 mgF/L). Categories of proteins based on GO annotation “Biological Process”. Terms significant (Kappa=0.04) and distribution acco... |
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MD5: ae2758f22e30c1cd8cc44c06841c533a
Subnetwork generated by ClusterMarker® for the comparison 10 mgF/L vs. control (0 mgF/L). The color of the node indicates the differential expression of the protein with its access code, obtained from UniProt protein database (http://www.uniprot.org/). Dark green and dark red nod... |
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MD5: 9aa77d9af5f7419840e8d9ad881b904e
Analysis in StringApp® application (CYTOSCAPE® 3.9.0 Software) containing 138 proteins found in the 10 mgF/L vs. control (0 mgF/L) group related to different metabolic pathways. The internal stains of the light green and light pink nodes indicate up-regulated and down-regulated p... |
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MD5: fac5a42094718ae45ea620238515ad4b
Protein-protein interaction network of histones and histone acetyltransferases. STRING database, version 11.0 (https://string-db.org/). The following proteins are present in the network: was identified network of evidence of histones: Histo1h2ak (Q8CGP7)- Histone H2A type 1-K, Hi... |
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MD5: b72236918ae133a4eb6a036922e36e30
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MS Excel Spreadsheet - 60.8 KB -
MD5: a7edba68150f48676ac50c47bc7ee144
Proteins expressed differentially or exclusively in the islets of non-obese |
