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Figure_1 - Representative images of a haematoxylin & eosin stained oral squamous cell carcinoma section demonstrating normoxic (N) areas with integrate blood microvessels (V), and hypoxic (H) compartments where distorted and packaged vessel structures with haemorrhagic spots (v)... |
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Figure_2 - Representative images of the immunohistochemical staining reactions of GLUT1, GLUT3, HK2, PFKL, PKM2, pPDH, LDHA, MCT4 and CAIX in oral potentially malignant disorders and in oral squamous cell carcinoma cases. |
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Figure_3 - Detailed heatmap on the immunoexpression results of GLUT1, GLUT3, HK2, PFKL, PKM2, pPDH, LDHA, MCT4 and CAIX in oral potentially malignant disorders and in oral squamous cell carcinoma (normoxic regions) cases, for the development of a glycolytic phenotype.
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Figure_4 - Kaplan-Meier curve demonstrating 3-year disease-free survival based on HK2 (A), and 3-year overall survival based on HK2 (B) and CAIX (C) immunoexpression status (normoxic regions), and on the glycolytic phenotype (according to the number of positive biomarkers) of pat... |
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Figure_5 - Immunoexpression of GLUT1, GLUT3, HK2, PFKL, PKM2, pPDH, LDHA and MCT4 in normoxic versus hypoxic compartments of oral squamous cell carcinoma cases. |
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Figure_6 - Kaplan-Meier curve demonstrating 3-year overall survival based on GLUT1 (A) and GLUT3 (B), and 3-year disease-free survival based on HK2 (C) immunoexpression status (hypoxic regions) of patients with oral squamous cell carcinoma. |
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Figure_S1 - Grading system used for the evaluation of immunohistochemistry results. |
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Figure_S2 - Representative images of the immunohistochemical staining reactions for GLUT1 in white oral lichen planus (A), oral leukoplakia without dysplasia (B), oral leukoplakia with low grade dysplasia (C), oral leukoplakia with high grade dysplasia (D) and oral squamous cell... |
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Figure_S3 - Representative images of the immunohistochemical staining reactions for GLUT3 in white oral lichen planus (A), oral leukoplakia without dysplasia (B), oral leukoplakia with low grade dysplasia (C), oral leukoplakia with high grade dysplasia (D) and oral squamous cell... |