Journal of Applied Oral Science

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441 to 450 of 720 Results

Figure_6.jpg Jan 2, 2023 - C5aR antagonist inhibits LPS-induced inflammation in human gingival fibroblasts via NF-κB and MAPK signaling pathways JPEG Image - 1007.0 KB - MD5: 09d779f58bb300917e8f61d7dab2e6f5 Figure 6. Effects of C5aR antagonists on NF-κB signaling pathway activation and TLR4 expression in LPS-stimulated HGFs.(A) Effects of C5aR antagonists on mRNA levels of p65, p-p65, IκBα, p-IκBα and TLR4 in LPS-stimulated HGFs.(B) Effects of C5aR antagonists on protein levels of p...
Figure_7.jpg Jan 2, 2023 - C5aR antagonist inhibits LPS-induced inflammation in human gingival fibroblasts via NF-κB and MAPK signaling pathways JPEG Image - 4.5 MB - MD5: 419a93b3d9988aea661ba0fb63c17492 Figure 7. The effects of C5aR antagonists on p-p65 translocation into the nucleus were used to detect by immunoflfluorescence staining.(A-C) LPS+C5aR antagonists group.(D-F) The control group.(G-I) LPS group. The Blue staining represented the nucleus; The green staining was p-p65...
Figure_8.jpg Jan 2, 2023 - C5aR antagonist inhibits LPS-induced inflammation in human gingival fibroblasts via NF-κB and MAPK signaling pathways JPEG Image - 975.9 KB - MD5: e31d40908889cc5a560522952d4d06e4 Figure 8. Effects of C5aR antagonists on MAPK signal pathway activation in LPS-stimulated HGFs.(A) Effects of C5aR antagonists on mRNA levels of JNK, p-JNK, c-JUN and p-c-JUN in LPS-stimulated HGFs. (B) Effects of C5aR antagonists on protein levels of JNK, p-JNK, c-JUN, and p-c-J...
Figure_S1.jpg Jan 2, 2023 - C5aR antagonist inhibits LPS-induced inflammation in human gingival fibroblasts via NF-κB and MAPK signaling pathways JPEG Image - 1.3 MB - MD5: cac855a33823ba41a8249455503be1e1 Figure S1. Effects of LPS and C5aRA on the activity of HGFs using the CCK8 assay. (A) HGFs were treated with LPS at concentrations of 0.1, 1, and 5 μg/mL for 24, 48, and 72 h, respectively. (B) HGFs were treated with C5aRA at concentrations of 0.1, 1, and 5 μg/mL for 24, 48, and...
Figure_S2.jpg Jan 2, 2023 - C5aR antagonist inhibits LPS-induced inflammation in human gingival fibroblasts via NF-κB and MAPK signaling pathways JPEG Image - 3.0 MB - MD5: 3d3960b130038f3421d122e3949ed393 Figure S2. Effects of different concentrations of LPS on the expression of C5aR, IL-1β, IL-6, and TNF-α mRNA, determined using RT-PCR analysis. (A) C5aR; (B) IL-6; (C) IL-1β; and (D) TNF-α mRNA expression. Data represent the mean ± SEM of three independent experiments. * P < 0.05...
Figure_S3.jpg Jan 2, 2023 - C5aR antagonist inhibits LPS-induced inflammation in human gingival fibroblasts via NF-κB and MAPK signaling pathways JPEG Image - 3.4 MB - MD5: 2663c792229305b8584174eccbf93ebe Figure S3. Effects of different concentrations of C5aRA on the expression of C5aR, IL-1β, IL-6, and TNF-α mRNA, determined using RT-PCR analysis. (A) C5aR; (B) IL-6; (C) IL-1β; and (D) TNF-α mRNA expression. Data represent the mean ± SEM of three independent experiments. * P < 0....
Graphical_Abstract.jpg Jan 2, 2023 - C5aR antagonist inhibits LPS-induced inflammation in human gingival fibroblasts via NF-κB and MAPK signaling pathways JPEG Image - 1.2 MB - MD5: 7c6fd5205e5631af918798512bb58073 Schematic diagram of mechanism for anti-inflammatory action of C5aR antagonists (W54011). Complement and Toll-like receptors 4 (TLR4) are co-activated in response to lipopolysaccharide (LPS). During the activation of the complement cascade, C5 may be cleaved into its active produ...
README.txt Jan 2, 2023 - C5aR antagonist inhibits LPS-induced inflammation in human gingival fibroblasts via NF-κB and MAPK signaling pathways Plain Text - 3.8 KB - MD5: 24501ebd59c9ae1e9855c1c58c36b01c
Figure_1.jpg Dec 20, 2022 - Microarray and bioinformatic analysis of conventional ameloblastoma JPEG Image - 3.3 MB - MD5: 200658a7622e53b2924a83205969b843 Figure 1 - PPI of the differentially expressed genes constructed using STRING online database and Cytoscape software analysis. a) A total of 31 differentially expressed genes were identified in the network. b) Module analysis via Cytoscape software (degree cutoff = 2, node score...
Figure_2.jpg Dec 20, 2022 - Microarray and bioinformatic analysis of conventional ameloblastoma JPEG Image - 2.2 MB - MD5: 1918b7583e1b0d003a39d6ba2dc91cb6 Figure 2 - A) Prognostic information of the 20 core genes. Kaplan-Meier plotter online tool was used to analyze the prognostic information and nine genes were found to be significantly associated with survival rate (* p < 0.05). B) Validation of the significant genes by GEPIA. T...

Figure_6.jpg

Jan 2, 2023 - C5aR antagonist inhibits LPS-induced inflammation in human gingival fibroblasts via NF-κB and MAPK signaling pathways

JPEG Image - 1007.0 KB -

Figure 6. Effects of C5aR antagonists on NF-κB signaling pathway activation and TLR4 expression in LPS-stimulated HGFs.(A) Effects of C5aR antagonists on mRNA levels of p65, p-p65, IκBα, p-IκBα and TLR4 in LPS-stimulated HGFs.(B) Effects of C5aR antagonists on protein levels of p...

Figure_7.jpg

Jan 2, 2023 - C5aR antagonist inhibits LPS-induced inflammation in human gingival fibroblasts via NF-κB and MAPK signaling pathways

JPEG Image - 4.5 MB -

Figure 7. The effects of C5aR antagonists on p-p65 translocation into the nucleus were used to detect by immunoflfluorescence staining.(A-C) LPS+C5aR antagonists group.(D-F) The control group.(G-I) LPS group. The Blue staining represented the nucleus; The green staining was p-p65...

Figure_8.jpg

Jan 2, 2023 - C5aR antagonist inhibits LPS-induced inflammation in human gingival fibroblasts via NF-κB and MAPK signaling pathways

JPEG Image - 975.9 KB -

Figure 8. Effects of C5aR antagonists on MAPK signal pathway activation in LPS-stimulated HGFs.(A) Effects of C5aR antagonists on mRNA levels of JNK, p-JNK, c-JUN and p-c-JUN in LPS-stimulated HGFs. (B) Effects of C5aR antagonists on protein levels of JNK, p-JNK, c-JUN, and p-c-J...

Figure_S1.jpg

Jan 2, 2023 - C5aR antagonist inhibits LPS-induced inflammation in human gingival fibroblasts via NF-κB and MAPK signaling pathways

JPEG Image - 1.3 MB -

Figure S1. Effects of LPS and C5aRA on the activity of HGFs using the CCK8 assay. (A) HGFs were treated with LPS at concentrations of 0.1, 1, and 5 μg/mL for 24, 48, and 72 h, respectively. (B) HGFs were treated with C5aRA at concentrations of 0.1, 1, and 5 μg/mL for 24, 48, and...

Figure_S2.jpg

Jan 2, 2023 - C5aR antagonist inhibits LPS-induced inflammation in human gingival fibroblasts via NF-κB and MAPK signaling pathways

JPEG Image - 3.0 MB -

Figure S2. Effects of different concentrations of LPS on the expression of C5aR, IL-1β, IL-6, and TNF-α mRNA, determined using RT-PCR analysis. (A) C5aR; (B) IL-6; (C) IL-1β; and (D) TNF-α mRNA expression. Data represent the mean ± SEM of three independent experiments. * P < 0.05...

Figure_S3.jpg

Jan 2, 2023 - C5aR antagonist inhibits LPS-induced inflammation in human gingival fibroblasts via NF-κB and MAPK signaling pathways

JPEG Image - 3.4 MB -

Figure S3. Effects of different concentrations of C5aRA on the expression of C5aR, IL-1β, IL-6, and TNF-α mRNA, determined using RT-PCR analysis. (A) C5aR; (B) IL-6; (C) IL-1β; and (D) TNF-α mRNA expression. Data represent the mean ± SEM of three independent experiments. * P < 0....

Graphical_Abstract.jpg

Jan 2, 2023 - C5aR antagonist inhibits LPS-induced inflammation in human gingival fibroblasts via NF-κB and MAPK signaling pathways

JPEG Image - 1.2 MB -

Schematic diagram of mechanism for anti-inflammatory action of C5aR antagonists (W54011). Complement and Toll-like receptors 4 (TLR4) are co-activated in response to lipopolysaccharide (LPS). During the activation of the complement cascade, C5 may be cleaved into its active produ...

README.txt

Jan 2, 2023 - C5aR antagonist inhibits LPS-induced inflammation in human gingival fibroblasts via NF-κB and MAPK signaling pathways

Plain Text - 3.8 KB -

Figure_1.jpg

Dec 20, 2022 - Microarray and bioinformatic analysis of conventional ameloblastoma

JPEG Image - 3.3 MB -

Figure 1 - PPI of the differentially expressed genes constructed using STRING online database and Cytoscape software analysis. a) A total of 31 differentially expressed genes were identified in the network. b) Module analysis via Cytoscape software (degree cutoff = 2, node score...

Figure_2.jpg

Dec 20, 2022 - Microarray and bioinformatic analysis of conventional ameloblastoma

JPEG Image - 2.2 MB -

Figure 2 - A) Prognostic information of the 20 core genes. Kaplan-Meier plotter online tool was used to analyze the prognostic information and nine genes were found to be significantly associated with survival rate (* p < 0.05). B) Validation of the significant genes by GEPIA. T...

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