A ideia de “constituições epidêmicas” é atribuída a Thomas Sydenham, um dos médicos mais eminentes do século XVII. Independentemente do tipo de epidemia de doença (cólera, gripe, varíola), ela visava explicar o que permanece inexplicável até hoje: Por que agora? E por que alguns desenvolvem doenças graves enquanto outros não? Neste artigo, reviso alguns debates que ocorreram durante as epidemias de cólera do século XIX, discuto a ideia de “constituições epidêmicas” telúricas e proponho uma reinterpretação, ou talvez apenas uma interpretação atualizada da incrível percepção de Thomas Sydenham sobre a causa das constituições epidêmicas: uma confluência entre uma causa excitante que estava na atmosfera e uma causa predisponente que estava nos corpos dos próprios sofredores. Com o que aprendemos desde então, explico sua percepção como representando o processo e o produto de nossa co-evolução com os vírus da Influenza A. Eu exploro teoricamente como essa interpretação explicaria diferenças em taxas e distribuições de infecção, doença e mortalidade durante epidemias e proponho explicações alternativas para a epidemiologia do surto inicial de COVID-19 na China e em países selecionados, com base em uma investigação epidemiológica sobre a circulação de vírus influenza durante a temporada de influenza de 2019-2020 nesses países. A abordagem levantou novas questões que só poderiam emergir do raciocínio epidemiológico (baseado na população) (o que causa vulnerabilidade?) e estudos epidemiológicos (qual era o contexto da influenza durante o surgimento da pandemia de COVID-19?), como: a) a Influenza B teve um papel na produção de vulnerabilidade à infecção pelo vírus SARS-COV2? b) o vírus SARS-COV2 e o vírus influenza H1N1 compartilham algum atributo imunológico condutivo a um mesmo tipo de resposta imunoinflamatória entre indivíduos não preparados para H1? Ou a sequência B-H1 e B-SARS_COV2 produzem morbidade semelhante? Uma sequência de B – H1 – SARS-COV2 explicaria a gravidade da Pandemia de COVID-19 nos EUA? Os vírus SARS-COV2 e os vírus H1N1 disputam o mesmo lugar ecológico? O que isso significaria para os desenvolvimentos futuros de nossa constituição imunoinflamatória?
CC BY 4.0
Use email button above to contact.
Our Community Norms as well as good scientific practices expect that proper credit is given via citation. Please use the data citation shown on the dataset page.
This file has already been deleted (or replaced) in the current version. It may not be edited.
Restricting limits access to published files. People who want to use the restricted files can request access by default. If you disable request access, you must add information about access to the Terms of Access field.
The selected file or files have already been published. Contact an administrator to change the embargo date or reason of the file or files.
The file will be deleted after you click on the Delete button.
Files will not be removed from previously published versions of the dataset.
Please select one or more files.
Share this dataset on your favorite social media networks.
Citations for this dataset are retrieved from Crossref via DataCite using Make Data Count standards. For more information about dataset metrics, please refer to the User Guide.
The selected file(s) may not be downloaded because you have not been granted access.
You may request access to the restricted file(s) by clicking the Request Access button.
The files selected are too large to download as a ZIP.
You can select individual files that are below the 100.0 MB download limit from the files table, or use the Data Access API for programmatic access to the files.
Please select a file or files to be downloaded.
The restricted file(s) selected may not be downloaded because you have not been granted access.
Click Continue to download the files you have access to download.
Are you sure you want to delete this dataset and all of its files? You cannot undelete this dataset.
Are you sure you want to delete this draft version? Files will be reverted to the most recently published version. You cannot undelete this draft.
Private URL can only be used with unpublished versions of datasets.
Are you sure you want to disable the Private URL? If you have shared the Private URL with others they will no longer be able to use it to access your unpublished dataset.
The file(s) will be deleted after you click on the Delete button.
This dataset contains restricted files you may not compute on because you have not been granted access.
Are you sure you want to deaccession? The selected version(s) will no longer be viewable by the public.
Are you sure you want to deaccession this dataset? It will no longer be viewable by the public.
Please select two versions to view the differences.
Please select a file or files for access request.
Embargoed files cannot be accessed. Please select an unembargoed file or files for your access request.
Select existing file tags or create new tags to describe your files. Each file can have more than one tag.
You need to Log In to request access.
This dataset is made available under the following terms. Please confirm and/or complete the information needed below in order to continue.
Upon downloading files the guestbook asks for the following information.
Account Information
Use the Download URL in a Wget command or a download manager to download this package file. Download via web browser is not recommended. User Guide - Downloading a Dataverse Package via URL
https://data.scielo.org/api/access/datafile/
Please confirm and/or complete the information needed below in order to request access to files in this dataset.
You will not be able to make changes to this dataset while it is in review.
Are you sure you want to republish this dataset?
Select if this is a minor or major version update.
This dataset cannot be published until SciELO Preprints is published by its administrator.
This dataset cannot be published until SciELO Preprints and SciELO Data are published.
Return this dataset to contributor for modification.
SciELO Data Support
Please fill this out to prove you are not a robot.
