Data for: Immunoexpression profile of hypoxia-inducible factor (HIF) targets in potentially malignant and malignant oral lesions: A pilot study

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Data for: Immunoexpression profile of hypoxia-inducible factor (HIF) targets in potentially malignant and malignant oral lesions: A pilot study
Afonso, Julieta; Gholami, Shakiba; Chamorro-Petronacci, Cintia; Pérez-Sayáns, Mario; Suárez Peñaranda, José; Longatto-Filho, Adhemar; Baltazar, Fátima, 2023, "Data for: Immunoexpression profile of hypoxia-inducible factor (HIF) targets in potentially malignant and malignant oral lesions: A pilot study", https://doi.org/10.48331/scielodata.QK4JEI, SciELO Data, V1, UNF:6:hPLEZ6XG3Zfk2Mec0kzS1g== [fileUNF]
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Description
The study aimed to evaluate the immunoexpression of the HIF targets GLUT1, GLUT3, HK2, PFKL, PKM2, pPDH, LDHA, MCT4 and CAIX in tissue samples from 34 patients with oral potentially malignant disorders and 34 patients with oral squamous cell carcinoma, in order to identify potential correlations between biomarkers’ immunoexpression, clinicopathological features and prognostic parameters. (2023-04-03)
Subject Medicine, Health and Life Sciences
Keyword Head and Neck Neoplasms, Monocarboxylic Acid Transporters, Warburg Effect, Oncologic
Related Publication Gholami S, Chamorro-Petronacci C, Pérez-Sayáns M, Suárez Peñaranda J, Longatto-Filho A, Baltazar F, Afonso J. Immunoexpression profile of hypoxia-inducible factor (HIF) targets in potentially malignant and malignant oral lesions: a pilot study. J Appl Oral Sci. 2023;31:e20220461. doi: 10.1590/1678-7757-2022-0461 doi: 10.1590/1678-7757-2022-0461
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Published Apr 17, 2023
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Figure_1 - Representative images of a haematoxylin & eosin stained oral squamous cell carcinoma section demonstrating normoxic (N) areas with integrate blood microvessels (V), and hypoxic (H) compartments where distorted and packaged vessel structures with haemorrhagic spots (v) are visible.
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Published Apr 17, 2023
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Figure_2 - Representative images of the immunohistochemical staining reactions of GLUT1, GLUT3, HK2, PFKL, PKM2, pPDH, LDHA, MCT4 and CAIX in oral potentially malignant disorders and in oral squamous cell carcinoma cases.
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Published Apr 17, 2023
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Figure_3 - Detailed heatmap on the immunoexpression results of GLUT1, GLUT3, HK2, PFKL, PKM2, pPDH, LDHA, MCT4 and CAIX in oral potentially malignant disorders and in oral squamous cell carcinoma (normoxic regions) cases, for the development of a glycolytic phenotype.
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Published Apr 17, 2023
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Figure_4 - Kaplan-Meier curve demonstrating 3-year disease-free survival based on HK2 (A), and 3-year overall survival based on HK2 (B) and CAIX (C) immunoexpression status (normoxic regions), and on the glycolytic phenotype (according to the number of positive biomarkers) of patients with oral squamous cell carcinoma.
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Published Apr 17, 2023
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Figure_5 - Immunoexpression of GLUT1, GLUT3, HK2, PFKL, PKM2, pPDH, LDHA and MCT4 in normoxic versus hypoxic compartments of oral squamous cell carcinoma cases.
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Figure_6 - Kaplan-Meier curve demonstrating 3-year overall survival based on GLUT1 (A) and GLUT3 (B), and 3-year disease-free survival based on HK2 (C) immunoexpression status (hypoxic regions) of patients with oral squamous cell carcinoma.
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Published Apr 17, 2023
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Figure_S1 - Grading system used for the evaluation of immunohistochemistry results.
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Published Apr 17, 2023
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Figure_S2 - Representative images of the immunohistochemical staining reactions for GLUT1 in white oral lichen planus (A), oral leukoplakia without dysplasia (B), oral leukoplakia with low grade dysplasia (C), oral leukoplakia with high grade dysplasia (D) and oral squamous cell carcinoma (E), as well as the positive control for GLUT1 (gastric carcinoma, F). Original magnifications of 40X (A and E), 100X (B, C, D) and 200X (F).
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Figure_S3 - Representative images of the immunohistochemical staining reactions for GLUT3 in white oral lichen planus (A), oral leukoplakia without dysplasia (B), oral leukoplakia with low grade dysplasia (C), oral leukoplakia with high grade dysplasia (D) and oral squamous cell carcinoma (E), as well as the positive control for GLUT3 (colorectal carcinoma, F). Original magnifications of 100X.
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Published Apr 17, 2023
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Figure_S4 - Representative images of the immunohistochemical staining reactions for HK2 in white oral lichen planus (A), oral leukoplakia without dysplasia (B), oral leukoplakia with low grade dysplasia (C), oral leukoplakia with high grade dysplasia (D) and oral squamous cell carcinoma (E), as well as the positive control for HK2 (gastric carcinoma, F). Original magnifications of 40X (F) and 100X (A, B, C, D, E).
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