Objetivo: Revisar a literatura científica sobre Estudos Clínicos Randomizados (ECR/Estudos Experimentais) e Estudos Clínicos não randomizados Controlados (ECC/Estudos Quase experimentais) que testaram os efeitos da prática de atividade física como intervenção em crianças e adolescentes com síndrome metabólica. Métodos: Este protocolo segue as recomendações PRISMA-P (Preferred reporting items for systematic review and meta-analysis protocols statement) para protocolos de revisões sistemáticas. Foram realizadas buscas em cinco bases de dadoseletrônicas indexadas: PubMed, Lilacs/BVS, Cochrane Library, além de buscas em uma base de dados da literatura cinzenta: Google Scholar. Foram utilizados descritores indexados no Medical Subject Headings (MeSH) e no Descritores em Ciências da Saúde (DeCS). Não foram aplicados limites em nenhuma das bases. O processo de seleção dos estudos será realizado de forma duplicada por dois pesquisadores independentes e se necessário, com auxílio de um terceiro para estabelecer consenso. Serão excluídos os artigos duplicados, lidos títulos e resumos e realizada a leitura de texto completo dos estudos elegíveis, além de buscas manuais nas listas de referências dos artigos selecionados; de acordo com os Principais itens para relatar Revisões sistemáticas e Meta-análises: a recomendação PRISMA. Resultados: Serão incluídos ECR e ECC sem restrição de idiomas. A qualidade metodológica será avaliada através do GRADEPRO. Discussão: Esta revisão sistemática apresentará uma síntese atual sobre os efeitos da prática de atividade física como intervenção em crianças e adolescentes com síndrome metabólica. Essas informações podem contribuir com a literatura científica relativa à área da Saúde de crianças e adolescentes e auxiliar na implementação de intervenções de saúde relacionadas à síndrome metabólica em crianças e adolescentes. Registro PROSPERO número: CRD42022355992.
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